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1,1-Dimethylbiguanide hydrochloride, Thermo Scientific™

Product Code. 15405619
100g
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Quantity:
5g
25g
100g
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

1,1-Dimethylbiguanide hydrochloride (metformin hydrochloride, CAS # 115-70-4) is the salt of methylated biguanide, a compound exhibiting anti-hyperglycemic properties.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1115-70-4
Molecular Formula C4H12ClN5
Molecular Weight (g/mol) 165.63
MDL Number MFCD00012582
InChI Key OETHQSJEHLVLGH-UHFFFAOYSA-N
Synonym metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
PubChem CID 14219
IUPAC Name hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
SMILES [H+].[Cl-].CN(C)C(=N)N=C(N)N

Specifications

Linear Formula NH2C(=NH)NHC(=NH)N(CH3)2·HCl
Quantity 100g
Merck Index 14,5938
Solubility Information Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
Formula Weight 165.62
Chemical Name or Material 1,1-Dimethylbiguanide hydrochloride

Safety and Handling

compliance-icons
Product Identifier
  • 1,1-Dimethylbiguanide hydrochloride
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
 Hazard Statement
  • H302-Harmful if swallowed.
  • H319-Causes serious eye irritation.
 Precautionary Statement
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contains : Metformin hydrochloride
SDS

RUO – Research Use Only

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