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Thermo Scientific™ 2'-Fluoro-Bz-A Phosphoramidite, standard grade, 28-400 finish bottle
2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis.
Brand: Thermo Scientific™ 27-1601-12
Description
2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.
Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C47H51FN7O7P
• Base: A
• Base Protection: Bz
• Formula weight: 875.92 g/mol
• HPLC purity: >98%
• 31P NMR purity: ≥98%

Specifications
MerMade Synthesizers | |
Store in freezer (at or below -20°C). | |
2in-Fluoro modified | |
98% | |
Phosphoramidite | |
RNA |
2in-Fluoro-Bz-A CEP | |
Adenosine (A) | |
Room Temperature | |
0.5 g | |
Standard | |
Powder |
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Lot Number | Certificate Type | Date | Catalog Number |
---|---|---|---|
XE2442 | Certificate of Analysis | 29/01/2025 | 27-1601-12 |
YE1432 | Certificate of Analysis | 29/01/2025 | 27-1601-12 |
YL0652 | Certificate of Analysis | 28/01/2025 | 27-1601-12 |
ZA3572 | Certificate of Analysis | 28/01/2025 | 27-1601-12 |
ZC1812 | Certificate of Analysis | 26/01/2025 | 27-1601-12 |
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