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Tocris Bioscience™ AC 710
Potent and selective PDGFR family inhibitor
Brand: Tocris Bioscience™ 5013/10
280.77 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.Specifications
| >99% | |
| 562.7 | |
| 10 mg |
| AC 710 | |
| AC 710 |
For Research Use Only