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CD209 Mouse anti-Human, APC, Clone: DCN46, BD

Mouse Monoclonal Antibody

Brand:  BD Biosciences 551545

Product Code. 15836688

  • 308.00€ / Each

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Description

Description

The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells.

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Specifications

Specifications

CD209
Monoclonal
APC
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Human Monocyte Derived DC Cells
100 Tests
Immunology
Human
IgG2b κ
Flow Cytometry
DCN46
DC-SIGN
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Product Title
CD209 Mouse anti-Human, APC, Clone: DCN46, BD > 100 Tests; APC

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