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AT 101, Tocris Bioscience™

Product Code. 18025082
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Quantity:
10 mg
50 mg
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Description

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Chemical Identifiers

CAS 90141-22-3
Molecular Formula C30H30O8
Molecular Weight (g/mol) 518.562
InChI Key QBKSWRVVCFFDOT-UHFFFAOYSA-N
Synonym gossypol, --gossypol, +-gossypol, pogosin, tash 1, racemic-gossypol, r---gossypol, r-gossypol, +--gossypol, +/--gossypol
PubChem CID 3503
ChEBI CHEBI:28584
IUPAC Name 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde
SMILES CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C

Specifications

Quantity 10 mg
Formula Weight 518.56
Percent Purity >98%
Chemical Name or Material AT 101
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