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Tocris Bioscience™ AZD 5582 dihydrochloride

Dimeric Smac mimetic; potent IAP inhibitor

Brand:  Tocris Bioscience™ 5141/10

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Product Code. 18709017

  • 294.00€ / 10mg
Estimated Shipment: 30-01-2025
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Description

Description

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.
Specifications

Specifications

>97%
AZD 5582 dihydrochloride
AZD 5582 dihydrochloride
10 mg
1088.21
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