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Tocris Bioscience™ Cercosporamide

Potent Mnk2 inhibitor

Brand:  Tocris Bioscience™ 4500/331U

Product Code. 18064672

  • 371.00€ / 331µg
Estimated Shipment: 30-01-2025
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Description

Description

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.
Specifications

Specifications

(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
331 μg
C16H13NO7
131436-22-1
Mnk Inhibitors
96%
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