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Chloroquine diphosphate, Tocris Bioscience™

Product Code. 18762474
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Quantity:
50 mg
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This item is not returnable. View return policy

Description

Antimalarial; inhibits apoptosis and autophagy

Chloroquine diphosphate is an antimalarial drug. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells. Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Specifications

CAS 50-63-5
Molecular Formula C18H32ClN3O8P2
MDL Number MFCD00069852
Quantity 50 mg
Synonym chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
InChI Key QKICWELGRMTQCR-UHFFFAOYNA-N
SMILES OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
IUPAC Name 7-chloro-N-[5-(diethylamino)pentan-2-yl]quinolin-4-amine; bis(phosphoric acid)
Molecular Weight (g/mol) 515.86
PubChem CID 64927
Formula Weight 515.86
Percent Purity >99%
Chemical Name or Material Chloroquine diphosphate
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