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CRALBP Recombinant Rabbit Monoclonal Antibody (HL1833), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Thermo Scientific MA550338

Product Code. 18095761

  • 450.00€ / 100µL
Estimated Shipment: 20-03-2025
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Description

Description

Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
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Product Title
CRALBP Recombinant Rabbit Monoclonal Antibody (HL1833), Invitrogen™ > 100 μL; Unconjugated

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