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Cucurbitacin I, Tocris Bioscience™

Product Code. 30001266
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of STAT3/JAK2 signaling

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Specifications

CAS 2222-07-3
Molecular Formula C30H42O7
Quantity 1 mg
Synonym (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
InChI Key NISPVUDLMHQFRQ-MKIKIEMVSA-N
SMILES CC1(C2=CCC3C4(CC(C(C4(CC(=O)C3(C2C=C(C1=O)O)C)C)C(C)(C(=O)C=CC(C)(C)O)O)O)C)C
IUPAC Name (9S,13S,14R,16S)-17-[(E,2S)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione
Molecular Weight (g/mol) 514.66
PubChem CID 17750994
Formula Weight 514.65
Percent Purity >98%
Chemical Name or Material Cucurbitacin I
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