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Thermo Scientific Chemicals D-Cycloserine, 98% Product Code.: 10646734
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Thermo Scientific Chemicals D-Cycloserine, 98%

Product Code. 10646734
25 g, Glass bottle
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5 g
25 g
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Glass bottle
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Product Code. 10646734

Brand: Thermo Scientific Chemicals 228480250

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Description

D-Cycloserine, CAS # 68-41-7, is a cyclic amino acid analog of D-alanine, originally isolated from Streptomyces species. It is synthetically formulated and exhibits antibiotic properties through its inhibition of bacterial cell wall synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

  • D-Cycloserine was originally isolated from Streptomyces orchidaceus and is currently formulated as an oral antibiotic
  • It is incompatible with strong oxidizing agents but stable under basic conditions, with the greatest stability at pH = 11.5
  • D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, 2 enzymes responsible for bacterial cell wall synthesis
  • When ingested, D-Cycloserine traverses the blood-brain barrier, potentially causing neurological side effects such as, dizziness, nausea, depression, tremors, etc.

Applications

  • D-Cycloserine is a broad-spectrum antibiotic used as a second line agent for treatment of drug-resistant tuberculosis, always in combination with other antituberculosis agents
  • It is an excitatory amino acid and partial agonist of the NMDA receptor in the central nervous system (CNS), thus playing a potential role in the amelioration of neuropathic pain
  • D-Cycloserine has also been shown to play a role in neural connectivity, and is therefore used to study treatment applications in anxiety disorders and schizophrenia
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 68-41-7
Molecular Formula C3H6N2O2
Molecular Weight (g/mol) 102.09
MDL Number MFCD00005353
InChI Key DYDCUQKUCUHJBH-UWTATZPHSA-N
Synonym d-cycloserine, cycloserine, seromycin, orientomycin, oxamycin, cyclorin, cyclo-d-serine, cicloserina, farmiserina, miroseryn
PubChem CID 6234
ChEBI CHEBI:40009
IUPAC Name (4R)-4-amino-1,2-oxazolidin-3-one
SMILES C1C(C(=O)NO1)N

Specifications

Absorbance Condensation products 0.8 max. (c=0.04, 0.1N NaOH) at 285nm
Melting Point 147.0°C
Color White to Yellow
pH 5.5 to 6.5 (10% soln.)
Ignition Residue 0.5% max. ()
Loss on Drying 1% max. (60°C, 3 hrs) (vacuum)
Infrared Spectrum Authentic
Assay Percent Range 98%
Packaging Glass bottle
Quantity 25 g
Merck Index 15,2749
Specific Rotation Condition +111.00 (20.00°C C=5,2N NaOH)
Specific Rotation + 111.00
Solubility Information Solubility in water: soluble. Other solubilities: slightly soluble in methanol and propylene glycol
Formula Weight 102.09
Percent Purity 98%
Physical Form Crystalline Powder or Crystals
Chemical Name or Material D-Cycloserine, 98+%
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Lot Number Certificate Type Date Catalog Number
Lot NumberA0436419 Certificate TypeCertificate of Analysis Date25/01/2025 Catalog Number228480250,228480010,228480050
Lot NumberA0467895 Certificate TypeCertificate of Analysis Date25/01/2025 Catalog Number228480250,228480010,228480050
Lot NumberA0465858 Certificate TypeCertificate of Analysis Date29/08/2024 Catalog Number228480250,228480010,228480050
Lot NumberA0464030 Certificate TypeCertificate of Analysis Date03/07/2024 Catalog Number228480250,228480010,228480050
Lot NumberA0459511 Certificate TypeCertificate of Analysis Date24/01/2024 Catalog Number228480250,228480010,228480050

Safety and Handling

Product Identifier
  • D-Cycloserine
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