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Doxycycline hydrochloride, Thermo Scientific Chemicals Product Code.: 15473189
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Doxycycline hydrochloride, Thermo Scientific Chemicals

Product Code. 15473189
5 g
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Quantity:
5 g
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Product Code. 15473189

Brand: Thermo Scientific Alfa Aesar J60422.06

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Description

Doxycycline hydrochloride, CAS # 10592-13-9, is the hydrochloride salt form of doxycycline that shows antibacterial and antimalarial activities.

Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinases.Doxycycline hydrochloride is an antibiotic used to inhibit matrix metalloproteinases like type 1 collagenase in studies on would healing and tissue remodeling. It shows the broad spectrum antibacterial and antiprotozoan activity. It is often used to treat lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Doxycycline hydrochloride is a compound that shows antibacterial and antimicrobial activities against several species, including Pseudomonas aeruginosa, Plasmodium falciparum, and Escherichia coli. It is also a bacteriostatic
  • It can block the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis

Application

  • It is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and eliminate Ixodes scapularis ticks
  • Doxycycline hydrochloride is also considered to be a broad-spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in wound healing and tissue remodeling studies. Due to this activity, it can inhibit angiogenesis and reduce lung metastases
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 10592-13-9
Molecular Formula C22H25ClN2O8
Molecular Weight (g/mol) 480.90
MDL Number MFCD03427564
InChI Key VLUQVUWDECWBTL-UQVCFKGQSA-N
PubChem CID 54706018
IUPAC Name (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chlorideShow MoreShow Less
SMILES [Cl-].C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H]([NH+](C)C)C(=O)\C(=C(/N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12

Specifications

Type Doxycycline Hydrochloride
Physical Form Crystalline Powder
Melting Point 195°C to 201°C
Color Yellow
Quantity 5 g
Solubility Information Soluble in water to 50mg/ml; May require warming.
Formula Weight 480.9
Chemical Name or Material Doxycycline hydrochloride

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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberN18L013 Certificate TypeCertificate of Analysis Date20/02/2025 Catalog NumberJ60422.06,J60422.14
Lot NumberY26K025 Certificate TypeCertificate of Analysis Date27/11/2024 Catalog NumberJ60422.06,J60422.14
Lot NumberU26K040 Certificate TypeCertificate of Analysis Date11/09/2024 Catalog NumberJ60422.06,J60422.14
Lot NumberS17K008 Certificate TypeCertificate of Analysis Date09/07/2024 Catalog NumberJ60422.06,J60422.14
Lot NumberM12K021 Certificate TypeCertificate of Analysis Date19/01/2024 Catalog NumberJ60422.06,J60422.14

Safety and Handling

compliance-icons
Product Identifier
  • Doxycycline hydrochloride
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H302-Harmful if swallowed.
  • H312-Harmful in contact with skin.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H332-Harmful if inhaled.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contains : Doxycycline hydrochloride
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