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Thermo Scientific Chemicals β-Estradiol, 98% Product Code.: 11916891
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Thermo Scientific Chemicals β-Estradiol, 98%

Product Code. 11916891
5 g, Glass bottle
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Quantity:
5 g
25 g
Packaging:
Glass bottle
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Product Code. 11916891

Brand: Thermo Scientific Chemicals 436320050

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Description

β-Estradiol, 98%, CAS # 50-28-2, is an estrogen steroid sex hormone that regulates several biological functions including gene transcription and protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• β-Estradiol is a naturally occurring endogenous hormone in females

• It is an important steroid sex hormone involved in the regulation of several biological functions including gene transcription and protein synthesis

• This hormone is produced by the ovaries and can bind to and activate specific nuclear receptors

Applications

• β-Estradiol acts as an estrogenic hormone receptor agonist and activator of PI 3-kinase

• It shows inhibitory activity against aldehyde oxidase

• β-Estradiol presents mild anabolic and metabolic activities and increases blood coagulability in vivo experiments

• It plays a role in immune and inflammatory processes

• β-Estradiol triggers an increase in hepatic synthesis of some proteins, including sex hormone-binding globulin (SHBG), and thyroid-binding globulin (TBG), and suppresses the formation of follicle-stimulating hormone (FSH)

• This compound has been used for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-28-2
Molecular Formula C18H24O2
Molecular Weight (g/mol) 272.38
InChI Key VOXZDWNPVJITMN-ZBRFXRBCSA-N
Synonym estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin
PubChem CID 5757
ChEBI CHEBI:16469
IUPAC Name (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
SMILES CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Specifications

CAS Min % 97.5
CAS Max % 100.0
Melting Point 176.0°C to 180.0°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass bottle
Quantity 5 g
Merck Index 15,3758
Specific Rotation +76° to +83° (20°C, 589nm) (c=1, dioxane)
Solubility Information Solubility in water: insoluble. Other solubilities: soluble in chloroform, hexane, ethyl acetate
Formula Weight 272.38
Percent Purity 98%
Physical Form Powder
Chemical Name or Material β-Estradiol
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberA0467870 Certificate TypeCertificate of Analysis Date31/01/2025 Catalog Number436320050,436320250
Lot NumberA0465822 Certificate TypeCertificate of Analysis Date30/08/2024 Catalog Number436320050,436320250
Lot NumberA0463030 Certificate TypeCertificate of Analysis Date27/05/2024 Catalog Number436320050,436320250
Lot NumberA0461383 Certificate TypeCertificate of Analysis Date04/04/2024 Catalog Number436320050,436320250
Lot NumberA0457454 Certificate TypeCertificate of Analysis Date03/11/2023 Catalog Number436320050,436320250

Safety and Handling

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Product Identifier
  • beta-Estradiol
 Signal Word
  • Danger
 Hazard Category
  • Carcinogenicity Category 1A
  • Reproductive toxicity on or via lactation
  • Reproductive toxicity Category 2
  • Specific target organ toxicity after repeated exposure Category 2
 Hazard Statement
  • H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H373-May cause damage to organs.
  • H362-May cause harm to breast-fed children.
  • H350-May cause cancer.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P202-Do not handle until all safety precautions have been read and understood.
  • P260-Do not breathe dust/fume/gas/mist/vapours/spray.
  • P263-Avoid contact during pregnancy/while nursing.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
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RUO – Research Use Only

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