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  6. 30001493

FK 228, Tocris Bioscience™

Product Code. 30001493
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

Potent and selective class I histone deacetylase inhibitor; antitumor

Potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts.

Specifications

CAS 128517-07-7
Molecular Formula C24H36N4O6S2
Quantity 1 mg
Synonym romidepsin
InChI Key OHRURASPPZQGQM-OYTWCIJESA-N
SMILES CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C
IUPAC Name (1S,7Z,10S,16Z)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Molecular Weight (g/mol) 540.694
PubChem CID 123135747
Formula Weight 540.7
Percent Purity >98%
Chemical Name or Material FK 228
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