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Tocris Bioscience™ FTIDC

Potent and selective negative allosteric modulator at mGlu1; also mGlu1 inverse agonist

Brand:  Tocris Bioscience™ 5000/10

Product Code. 18701078

  • 293.00€ / 10mg
Estimated Shipment: 29-01-2025
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Description

Description

FTIDC is a potent and selective mGlu1 receptor negative allosteric modulator (IC50 values are 5.8 and 6200 nM for mGlu1 and mGlu5 respectively). Also acts as an mGlu1 receptor inverse agonist (IC50 = 7 nM) in the absence of ligand. Exhibits no effect at group II/III mGlu receptors. Inhibits L-glutamate-induced increases in intracellular calcium in mGlu1-expressing CHO cells. Inhibits nociceptive behavior, and exhibits anxiolytic and antipsychotic effects in vivo. Orally active.
Specifications

Specifications

>98%
FTIDC
FTIDC
10 mg
358.41
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