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Indomethacin, 99+%, Thermo Scientific Chemicals Product Code.: 15435529
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Indomethacin, 99+%, Thermo Scientific Chemicals

Product Code. 15435529
5 g
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Quantity:
1 g
5 g
25 g
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Product Code. 15435529

Brand: Thermo Scientific Alfa Aesar J63255.06

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Description

Indomethacin, CAS # 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID).

Non-selective cyclooxygenase inhibitorIndomethacin acts as an antiinflammatory, antipyretic and analgesic. It serves as an inhibitor cyclooxygenase such as Cox-1 and Cox-2. In addition to this, it is used as a prescription medication in order to reduce fever, stiffness, swelling and pain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Indomethacin is a synthetic NSAID of the indole family that inhibits cyclooxygenase and reduces prostaglandin and pyrogen release
  • Indomethacin may suppress the multi-drug resistant transporter and thereby increase the efficacy of antineoplastics
  • Indomethacin activates phosphatases that inhibit signaling pathways associated with cancer cell migration and proliferation

Applications

  • Indomethacin may be used for the laboratory study of cancer cell proliferation, tumorigenesis and drug interactions
  • Indomethacin may be used for laboratory study of the effect of inhibiting the multi-drug resistance transporter, or for downregulation of survival signaling in cells via survivin
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53-86-1
Molecular Formula C19H16ClNO4
Molecular Weight (g/mol) 357.79
MDL Number MFCD00057095
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Synonym indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
PubChem CID 3715
ChEBI CHEBI:49662
IUPAC Name 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
SMILES CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

Melting Point 158°C to 161°C
Color White
Quantity 5 g
UN Number UN2811
Beilstein 497341
Sensitivity Light sensitive
Merck Index 14,4968
Solubility Information Soluble in ethanol and dimethyl sulfoxide.
Formula Weight 357.8
Percent Purity ≥99%
Physical Form Powder
Chemical Name or Material Indomethacin
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberU21K027 Certificate TypeCertificate of Analysis Date25/09/2024 Catalog NumberJ63255.06,J63255.03,J63255.14
Lot NumberY18H017 Certificate TypeCertificate of Analysis Date17/11/2022 Catalog NumberJ63255.06,J63255.03,J63255.14
Lot NumberX26C032 Certificate TypeCertificate of Analysis Date08/12/2021 Catalog NumberJ63255.06,J63255.03,J63255.14
Lot NumberM13C066 Certificate TypeCertificate of Analysis Date08/12/2021 Catalog NumberJ63255.06,J63255.03,J63255.14
Lot NumberZ11B015 Certificate TypeCertificate of Analysis Date08/12/2021 Catalog NumberJ63255.06,J63255.03,J63255.14

Safety and Handling

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Product Identifier
  • Indomethacin
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 2
  • Reproductive toxicity Category 1B
  • Skin sensitiser Category 1
 Hazard Statement
  • H300-Fatal if swallowed.
  • H317-May cause an allergic skin reaction.
  • H360FD-May damage fertility. May damage the unborn child.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
  • P405-Store locked up.
 Supplemental information
  • MIXTURE LIST-Contains : Indomethacin
SDS

RUO – Research Use Only

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