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ITPA Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA588421
This item is not returnable.
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Description
Immunogen sequence: MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR ALLELQEYFG SLAA; Positive Samples: U-87MG, HT-29, Mouse small intestine, Mouse heart, Rat liver; Cellular Location: Cytoplasm
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Specifications
| ITPA | |
| Polyclonal | |
| Unconjugated | |
| ITPA | |
| 2010016I08Rik, AU020102, C20orf37, dJ794I6.3, HAMAP-Rule:MF_03148}, HLC14-06-P, inosine triphosphatase, inosine triphosphatase (nucleoside triphosphate pyrophosphatase), inosine triphosphatase {ECO:0000255, inosine triphosphate pyrophosphatase, inosine triphosphate pyrophosphatase {ECO:0000255, inosine triphosphate pyrophosphohydrolase, Itp, ITPA, ITPase, ITPase {ECO:0000255, My049, My049 protein, Non-canonical purine NTP pyrophosphatase, non-canonical purine NTP pyrophosphatase {ECO:0000255, non-standard purine NTP pyrophosphatase, non-standard purine NTP pyrophosphatase {ECO:0000255, NTPase, NTPase {ECO:0000255, nucleoside triphosphate pyrophosphatase, nucleoside-triphosphate diphosphatase, nucleoside-triphosphate diphosphatase {ECO:0000255, Nucleoside-triphosphate pyrophosphatase, nucleoside-triphosphate pyrophosphatase {ECO:0000255, OK/SW-cl.9, Putative oncogene protein hlc14-06-p | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 16434, 311422, 3704 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.58 mg/mL | |
| PBS with 50% glycerol and 0.01% thimerosal, pH 7.3 | |
| D3ZW55, Q9BY32, Q9D892 | |
| ITPA | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human ITPA (NP_2584121) | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |