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  5. Tocris Bioscience™ Ivosidenib

Tocris Bioscience™ Ivosidenib

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

165.00€ - 609.00€

Specifications

Chemical Name or Material (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
CAS 1448347-49-6
Target Isocitrate Dehydrogenase 1/IDH1
Molecular Formula C28H22ClF3N6O3
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Tocris Bioscience™
7761/10 		10 mg
165.00€
10mg
Estimated Shipment: 30-01-2025
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Tocris Bioscience™
7761/50 		50 mg
609.00€
50mg
Estimated Shipment: 30-01-2025
to see stock.
Add to basket
 
Description

Description

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.
Specifications

Specifications

(2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
1448347-49-6
Isocitrate Dehydrogenase 1/IDH1
C28H22ClF3N6O3
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Safety and Handling

Safety and Handling

Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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