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Tocris Bioscience™ LYN 1604 dihydrochloride
Potent UNC-51-like kinase 1 (ULK1) agonist
Specifications
| Chemical Name or Material | 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride |
|---|---|
| CAS | 2310109-38-5 |
| Target | ULK1 |
| Molecular Formula | C33H43Cl2N3O2.2HCl |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18747706
|
Tocris Bioscience™
6617/10 |
10 mg |
N/A
|
N/A | |||||
|
18748106
|
Tocris Bioscience™
6617/50 |
50 mg |
N/A
|
N/A | |||||
Description
LYN 1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) agonist (EC50 = 18.94 nM). In MDA-MB-231 cells, LYN 1604 induces upregulation of Beclin-1, LC3-I and LC3-II, as well as degradation of p62. LYN 1604 induces cell death (IC50 = 1.66 μM) via the ULK complex involving both autophagy and apoptosis pathway effectors (e.g. ATF3, RAD21, and caspase-3); this effect is reversible by the autophagy inhibitor 3-methyladenine (Cat. No. 3977). LYN 1604 inhibits tumor growth in a mouse xenograft model, decreases bone loss in a mouse model of osteoporosis and reduces the formation of TRAP-positive multinucleated cells.Specifications
| 2-[Bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]ethanone dihydrochloride | |
| 2310109-38-5 | |
| ULK1 | |
| C33H43Cl2N3O2.2HCl |
Safety and Handling
Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.