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N,N'-Dicyclohexylcarbodiimide, 99%, Thermo Scientific Chemicals
Description
N,N'-Dicyclohexylcarbodiimide is a carboxyl activating reagent used in peptide synthesis. It acts as a dehydrating agent for the preparation of amides, ketones and nitriles. It is involved in the preparation of esters by reacting tertiary alcohols with carboxylic acid. It is utilized for the stereo chemical inversion of secondary alcohols by forming formyl ester followed by saponification. It is associated with dimethyl sulfoxide and used in Pfitzner-Moffatt oxidation to convert alcohols into aldehydes and ketones.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
N,N′-Dicyclohexylcarbodiimide is a carboxyl activating reagent used in peptide synthesis. It acts as a dehydrating agent for the preparation of amides, ketones and nitriles. It is involved in the preparation of esters by reacting tertiary alcohols with carboxylic acid. It is utilized for the stereo chemical inversion of secondary alcohols by forming formyl ester followed by saponification. It is associated with dimethyl sulfoxide and used in Pfitzner-Moffatt oxidation to convert alcohols into aldehydes and ketones.
Solubility
Soluble in methanol, chloroform, dichloromethane, acetonitrile, tetrahydrofuran and dimethylformamide. Insoluble in water.
Notes
Incompatible with strong oxidizing agents.
Specifications
Specifications
| Melting Point | 33°C to 36°C |
| Boiling Point | 154°C to 156°C (11 mmHg) |
| Flash Point | 138°C (280°F) |
| Quantity | 25 g |
| UN Number | UN2811 |
| Beilstein | 610662 |
| Sensitivity | Moisture sensitive |
| Merck Index | 14,3096 |
| Solubility Information | Soluble in methanol,chloroform,dichloromethane,acetonitrile,tetrahydrofuran and dimethylformamide. Insoluble in water. |
| Formula Weight | 206.33 |
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Safety and Handling
- N,N'-Dicyclohexylcarbodiimide
- Danger
- Acute toxicity Category 3
- Acute toxicity Category 4
- LONG-TERM AQUATIC HAZARD Chronic 1
- ACUTE AQUATIC Acute 1
- Serious eye damage/eye irritation Category 1
- Skin sensitiser Category 1
- H302-Harmful if swallowed.
- H311-Toxic in contact with skin.
- H317-May cause an allergic skin reaction.
- H318-Causes serious eye damage.
- H400-Very toxic to aquatic life.
- H410-Very toxic to aquatic life with long lasting effects.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- MIXTURE LIST-Contains : Dicyclohexylcarbodiimide
RUO – Research Use Only