missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Phospho-ATR (Thr1989) Recombinant Rabbit Monoclonal Antibody (PS01-18), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen MA545973
This item is not returnable.
View return policy
Description
Predicted band size: 301 kDa Positive Control: HeLa cell lysate, HeLa treated with Hydroxyurea cell lysate, HeLa treated with 4mM Hydroxyurea for 20 hours. Subcellular Location: Chromosome, Nucleus. Sequence Similarities: No Cross with Mouse and Rat. Tissue Specificity: Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Specifications
| Phospho-ATR (Thr1989) | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide | |
| Q13535 | |
| ATR | |
| Synthetic peptide. | |
| 100 μL | |
| Primary | |
| Human | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| PS01-18 | |
| Unconjugated | |
| ATR | |
| 2310008J16Rik; 2810405N18Rik; ataxia telangiectasia and Rad3 related; ataxia telangiectasia and Rad3-related protein; ATR; ATR serine/threonine kinase; EC 2.7.11.1; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; I79_000761; kinase ATR; MEC1; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; SCKL; SCKL1; Serine/threonine-protein kinase ATR; TEM8 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 545 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| IgG |