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Thermo Scientific™ Pierce™ Iodination Reagent (1,3,4,6-tetrachloro-3α,6α-diphenyl-glycoluril)
Activate iodine for incorporation of iodine-125 labels into protein tyrosyl groups using this tetrachloro-diphenyl-glycoluril oxidizing agent.
Brand: Thermo Scientific™ 28600
This item is not returnable.
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Description
Thermo Scientific™ Pierce Iodination Reagent is 1,3,4,6-tetrachloro-3a,6a-diphenyl-glycoluril, an oxidizing agent that efficiently activates iodine for spontaneous incorporation into protein tyrosyl groups.
Unlike chloramine-T, Pierce Iodination Reagent can be coated on glassware to enable solid-phase iodine-labeling. As a result, reducing agents are not necessary in the procedure.Highlights:
- Extremely stable and virtually insoluble in water
- Solubility in chloroform permits plating aliquots of the reagent on the walls of the glass or plastic iodination vessels; plated vessels can be prepared in advance and stored in a dessicator
- Allows rapid iodination of proteins in an aqueous reaction mixture containing radioactive Na125I
- Side reactions are negligible
- No reducing reagent is required because reactions are terminated by simply decanting the reaction solution away from the plated iodination reagent
- Specific activities of 10,000cpm of 125I per microgram of protein and labeling efficiencies of 60% are easily achieved
- Can be used to iodinate phenolic groups on crosslinkers or other protein modification reagents either before or after a protein, peptide or cell surface is reacted with the modification reagent
- Small amounts of protein can be iodinated
- More efficient than Chloramine-T or Lactoperoxidase
- Iodinate phenolic groups on crosslinking reagents
Specifications
| Iodination Reagent | |
| Upon receipt store refrigerated and desiccated. Product shipped at ambient temperature. | |
| Iodine-125 |
| 1 g | |
| Pierce™ | |
| Radioisotope |
For Research Use Only. Not for use in diagnostic procedures.