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Poly(I:C), Tocris Bioscience™

Product Code. 30001395
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

TLR3 agonist

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo. Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 . Transfection into NIT-1 β cells induce β-cell apoptosis. Commonly used to stimulate immune system activation in vivo. Also promotes maturation of hPSC-derived cardiomyocytes.

To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

Chemical Identifiers

CAS 24939-03-5
Molecular Formula C19H27N7O16P2
Molecular Weight (g/mol) 671.406
InChI Key ACEVNMQDUCOKHT-YJZUVTEISA-N
Synonym poly i:c
PubChem CID 124080975
IUPAC Name [(2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O

Specifications

Quantity 10 mg
Percent Purity >98%
Chemical Name or Material Poly(I:C)
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