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Tocris Bioscience™ EPZ 004777

Highly potent DOT1L inhibitor

Brand:  Tocris Bioscience™ 5567/10

281.63 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.

Product Code. 18708588

  • 357.00€ / 10mg
Estimated Shipment: 28-11-2024
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Description

Description

EPZ 004777 is a highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL-rearranged cells in vitro. Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.
Specifications

Specifications

EPZ 004777
7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Soluble to 100mM in DMSO and to 100mM in ethanol
539.67
Bioactive Small Molecule
1338466-77-5
10 mg
C28H41N7O4
Solid
>98%
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Research Use Only. Not For Human or Veterinary Use