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STEMCELL Technologies Ruxolitinib
JAK/STAT pathway inhibitor; Inhibits JAK1 and JAK2
95.85€ - 351.00€
Specifications
| CAS | 941678-49-5 |
|---|---|
| Synonym | INCB 018424, INC 424 |
| Molecular Formula | C17H18N6 |
| Purity | ≥98% |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17100222
|
STEMCELL Technologies
73404 |
10 mg |
351.00€
10mg |
Estimated Shipment: 24-01-2025
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|
17190212
|
STEMCELL Technologies
73402 |
1 mg |
95.85€
1mg |
Estimated Shipment: 08-01-2025
Log in to see stock. |
|||||
Description
- Ruxolitinib is an ATP mimic that inhibits all Janus-associated kinase (JAK) family kinases with a preference for JAK-1 and JAK-2 over JAK-3 and TYK2 with IC50 values of 3.3, 2.8, 428 and 19 nM respectively (Verstovsek; Quintás-Cardama et al.)
- Suppresses erythroid progenitor colony formation from peripheral blood mononuclear cells of polycythemia vera patients with the constitutively active JAK2 V617F mutation
- Reduces malignant cell proliferation and decreases interleukin-6 and TNF-α signaling in a JAK2 V617F-driven mouse model of myeloproliferative disorder (Quintás-Cardama et al.)
- Promotes hair regrowth in a mouse model of alopecia areata (Xing et al.)
Specifications
| 941678-49-5 | |
| INCB 018424, INC 424 | |
| C17H18N6 | |
| ≥98% |
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