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SB 202190, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.
Specifications
Specifications
Quantity | 10 mg |
Formula Weight | 331.35 |
Percent Purity | >99% |
Chemical Name or Material | SB 202190 |
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