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  6. SB 202190, Tocris Bioscience™

SB 202190, Tocris Bioscience™

Product Code. 30001220
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.

Chemical Identifiers

CAS 152121-30-7
Molecular Formula C20H14FN3O
Molecular Weight (g/mol) 331.35
MDL Number MFCD00941964
InChI Key NJNKPVPFGLGHPA-UHFFFAOYSA-N
Synonym fhpi, unii-pvx798p8gi, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl imidazole, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl-1h-imidazole, pvx798p8gi, sb 202190, immobilized, insolution sb 202190, 4-4-4-fluorophenyl-5-pyridin-4-yl-1h-imidazol-2-yl phenol, phenol, 4-4-4-fluorophenyl-5-4-pyridinyl-1h-imidazol-2-yl
PubChem CID 5353940
IUPAC Name 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one
SMILES FC1=CC=C(C=C1)C1=C(NC(N1)=C1C=CC(=O)C=C1)C1=CC=NC=C1

Specifications

Quantity 10 mg
Formula Weight 331.35
Percent Purity >99%
Chemical Name or Material SB 202190
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