missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. SB 202190, Tocris Bioscience™

SB 202190, Tocris Bioscience™

Product Code. 30001220
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective inhibitor of p38 MAPK

SB 202190 is a highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Inhibits Yamanaka factor reprogramming of human fibroblasts to iPSCs. SB 202190 improves the self-renewal ability of neuronal stem cells from NPC1-deficient mice.

Chemical Identifiers

CAS 152121-30-7
Molecular Formula C20H14FN3O
Molecular Weight (g/mol) 331.35
MDL Number MFCD00941964
InChI Key NJNKPVPFGLGHPA-UHFFFAOYSA-N
Synonym fhpi, unii-pvx798p8gi, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl imidazole, 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridyl-1h-imidazole, pvx798p8gi, sb 202190, immobilized, insolution sb 202190, 4-4-4-fluorophenyl-5-pyridin-4-yl-1h-imidazol-2-yl phenol, phenol, 4-4-4-fluorophenyl-5-4-pyridinyl-1h-imidazol-2-yl
PubChem CID 5353940
IUPAC Name 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydro-1H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one
SMILES FC1=CC=C(C=C1)C1=C(NC(N1)=C1C=CC(=O)C=C1)C1=CC=NC=C1

Specifications

Quantity 10 mg
Formula Weight 331.35
Percent Purity >99%
Chemical Name or Material SB 202190
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.