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STEMCELL Technologies Tamoxifen Product Code.: 17140102
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STEMCELL Technologies Tamoxifen

Product Code. p-7217640
500 mg, 500mg
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Quantity:
500 mg
5 g
10 g
Unit Size:
10g
500mg
5g
This item is not returnable. View return policy

Product Code. 17140102

Brand: STEMCELL Technologies 72662

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This item is not returnable. View return policy

Description

Estrogen signaling pathway modulator; Modulates selective estrogen receptor and estrogen-related receptor

  • Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
  • Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
  • Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
  • Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
  • Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
  • Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)

Specifications

CAS 10540-29-1
Synonym trans-Tamoxifen
Quantity 500 mg
Molecular Formula C26H29NO
Purity ≥95%
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