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  8. Tamoxifen, 98%, Thermo Scientific Chemicals

Tamoxifen, 98%, Thermo Scientific Chemicals

Product Code. 15495719
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Quantity:
500 mg
1 g
5 g

Description

Tamoxifen (citofen, CAS # 10540-29-1) is an antineoplastic agent that has its effect through the estrogen receptors.

Inhibitor of protein kinase C and induces apoptosis in cancer cells. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Tamoxifen is a tertiary aminobenzene that acts by competitively binding and antagonizing estrogen receptors to reduce DNA synthesis
  • When estradiol cannot bind estrogen receptors, the DNA response element is not activated
  • Tamoxifen upregulates the production of TGFb and slows tumor growth
  • Tamoxifen inhibits the production of IGF-1, a stimulator of tumor growth

Application

  • Tamoxifen may be useful in the study of tumorigenesis, growth, and inflammation
  • It is suitable for in vitro experiments
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 10540-29-1
Molecular Formula C26H29NO
Molecular Weight (g/mol) 371.52
MDL Number MFCD00010454
InChI Key NKANXQFJJICGDU-QPLCGJKRSA-N
Synonym tamoxifen, trans-tamoxifen, crisafeno, soltamox, tamoxifene, diemon, tamoxifeno, tamoxifenum, citofen, istubol
PubChem CID 2733526
ChEBI CHEBI:41774
IUPAC Name (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
SMILES CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1

Specifications

Color White
Quantity 500 mg
Merck Index 14,9048
Solubility Information Insoluble in water; Soluble in methanol,ethanol,propanol or propylene glycol;Soluble in dimethyl sulfoxide,dichloromethane and ethanol; Insoluble in water.
Formula Weight 371.52
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Tamoxifen

Safety and Handling

compliance-icons compliance-icons
Product Identifier
  • Tamoxifen
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • Carcinogenicity Category 1A
  • Reproductive toxicity on or via lactation
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H302-Harmful if swallowed.
  • H350-May cause cancer.
  • H360FD-May damage fertility. May damage the unborn child.
  • H362-May cause harm to breast-fed children.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P263-Avoid contact during pregnancy/while nursing.
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contains : Tamoxifen

RUO – Research Use Only

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