Applied Biosystems™ TaqMan™ Array Human Alzheimer's Disease

Description

The panel of assays in this plate is based on the amyloid hypothesis. The 92 genes are involved in APP processes that generate beta-amyloid and included genes implicated in multiple secondary steps of beta-amyloid aggregation, tau hyperphosphorylation, excitotoxicity, inflammation, oxidation and microglial activation. We also include assays for genes involved in cholesterol biosynthesis due to the correlation between high cholesterol and increased risk of Alzheimer's. Genes associated with Alzheimer's disease pathology, biochemistry and genetics are also included. Gene Signature Plates are 96-well plates that are pre-configured with the most appropriate TaqMan Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment.

TaqMan Array Plates contain the same TaqMan Gene Expression Assays that have been available for years in a convenient, 96-well format. Extensive tests have found no difference in performance between TaqMan Assays supplied in the traditional format and assays dried into a TaqMan Array Plate.

Each pack of plates is shipped with a CD containing the plate map along with details of each assay. This information is imported into the real-time PCR instrument to enable proper labeling of data and access to Assay ID numbers for simple reordering.

• Affordable; minimum order of three plates; ideal for small, medium or large-sized projects
• Fast delivery; on your bench in days
• Convenient; dried PCR primer and TaqMan™ probe sets supplied in a 96- well plate; just add master mix and your sample
• TaqMan Array Plates have been optimized for use with TaqMan Gene Expression Master Mix, but are also compatible with TaqMan Universal PCR Master Mix
• For studies using cultured cells, TaqMan Array Plates are also compatible (and recommended) with the TaqMan Gene Expression Cells-to-Ct™ Kit
• TaqMan™ Array Plates must be run on a real-time PCR instrument with 96-well plate capability
• The plates have been validated for use on Applied Biosystems™ 7000, 7300, 7500 and 7900HT Fast Real-Time PCR Systems using standard 96-well blocks, standard PCR cycling conditions, and 20μL reaction.