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Thiamet G, Tocris Bioscience™

Product Code. 18005142
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent O-GlcNAcase inhibitor

Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Specifications

CAS 1009816-48-1
Molecular Formula C9H16N2O4S
Quantity 10 mg
Synonym thiamet g
InChI Key PPAIMZHKIXDJRN-LQOSVEJXSA-N
SMILES CCNC1=NC2C(C(C(OC2S1)CO)O)O
IUPAC Name (3aS,5R,6R,7S,7aS)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
Molecular Weight (g/mol) 248.297
PubChem CID 122172999
Formula Weight 248.3
Percent Purity >98%
Chemical Name or Material Thiamet G
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