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  6. YM 244769, Tocris Bioscience™

YM 244769, Tocris Bioscience™

Product Code. 30001586
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective

Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Chemical Identifiers

CAS 1780390-65-9
Molecular Formula C26H23ClFN3O3
Molecular Weight (g/mol) 479.936
InChI Key NCLYRVYCCUZJEZ-UHFFFAOYSA-N
Synonym N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
PubChem CID 131698732
IUPAC Name N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]pyridine-3-carboxamide;hydrochloride
SMILES C1=CC(=CC(=C1)N)CNC(=O)C2=CN=C(C=C2)OC3=CC=C(C=C3)OCC4=CC(=CC=C4)F.Cl

Specifications

Quantity 50 mg
Formula Weight 516.39
Percent Purity >99%
Chemical Name or Material YM 244769
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