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Crosslinking Reagents

Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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1 – 13 of 13 results
1

Thermo Scientific™ SM(PEG)2 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description SM(PEG)2
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 425.39
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 17.6 Å
Product Line Pierce™
PEGylated Yes
2

Thermo Scientific™ SM(PEG)4 (PEGylated SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description SM(PEG)4
Cleavable No
Water Soluble Yes
Form Solid
Molecular Weight (g/mol) 513.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 24.6 Å
Product Line Pierce™
PEGylated Yes
3

Thermo Scientific™ SM(PEG)12 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

Shipping Condition Ambient
Content And Storage Upon receipt store desiccated at -20°C.
Description SM(PEG)12
Cleavable No
Water Soluble Yes
Form Liquid
Molecular Weight (g/mol) 865.92
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Sulfhydryl
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Long (>30 Å)
Reactive Moiety Maleimide, NHS Ester
Spacer Arm Length 53.4 Å
Product Line Pierce™
PEGylated Yes
4

Thermo Scientific™ BS(PEG)9

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

5

Thermo Scientific™ BS(PEG)5 (PEGylated bis(sulfosuccinimidyl)suberate)

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Content And Storage Upon receipt store desiccated at -20°C.
Description BS(PEG)5
Cleavable No
Water Soluble Yes
Molecular Weight (g/mol) 532.5
Solubility Water
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Chemical Reactivity Amine-Amine
Cell Permeability No
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety NHS Ester
Spacer Arm Length 21.7 Å
PEGylated Yes
6

Thermo Scientific™ BM(PEG)2 (1,8-bismaleimido-diethyleneglycol)

Crosslink sulfhydryls to sulfhydryls (cysteine residues) with this long, pegylated, water-soluble crosslinker composed of maleimide groups and 2-unit (14.7A) PEG spacer arm.

7

Thermo Scientific™ SM(PEG)8 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

8

Thermo Scientific™ SM(PEG)24 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

9

Thermo Scientific Pierce™ Pierce™ SM(PEG)12, No-Weigh™ Format

Thermo Scientific™ Pierce™ SM(PEG)12 is hetero-bifunctional crosslinker with N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules.

10

Thermo Scientific™ SM(PEG)6 (PEGylated, long-chain SMCC crosslinker)

Crosslink amines to sulfhydryls with these crosslinkers containing NHS-ester and maleimide groups at ends of water-soluble polyethylene glycol spacer arms (17.6 to 95.2A).

11

Thermo Scientific™ EZ-Link™ TFP Ester-PEG4-DBCO

An amine reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The crosslinker can be used to label a variety of amine containing molecules such as proteins, biomolecules, or small molecules.

Shipping Condition Wet Ice
Content And Storage Upon receipt store desiccated at -20°C.
Description TFP Ester-PEG4-DBCO
Cleavable No
Water Soluble No
Molecular Weight (g/mol) 714.7
Solubility DMF, DMSO
Quantity 10 x 1 mg
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Amine-Azide
Cell Permeability Not determined
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety TFP Ester, DBCO
Spacer Arm Length 17.9 Å
Product Line EZ-Link™ No-Weigh™
PEGylated Yes
12

Thermo Scientific™ EZ-Link™ Maleimide-PEG4-DBCO

A sulfhydryl reactive heterobifunctional crosslinker which contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. The thiol/sulfhdryl reactive maleimide can be used to label a variety of thiol containing moieties such as free cystines in proteins, peptides, or other (bio)molecules.

EDGE
Shipping Condition Wet Ice
Content And Storage Upon receipt store desiccated at -20°C.
Description Maleimide-PEG4-DBCO
Cleavable No
Water Soluble No
Molecular Weight (g/mol) 647.74
Solubility DMF, DMSO
Quantity 10 x 1 mg
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Chemical Reactivity Azide-Sulfhydryl
Cell Permeability Not determined
Format Standard, Single-use
Product Type Crosslinker
Spacer Medium (10 to 30 Å)
Reactive Moiety Maleimide, DBCO
Spacer Arm Length 29.7 Å
Product Line EZ-Link™ No-Weigh™
PEGylated Yes
13

Thermo Scientific™ EZ-Link™ Biotin-PEG12-DBCO

EZ-Link Biotin-PEG12-DBCO is a biotinylation reagent that contains a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry attachment to an azide-labeled molecule, enabling the attachment of biotin using a bioorthogonal approach.