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BAY 678

Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor

Brand: Tocris Bioscience 5706/5

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Product Code. 18739278

118.00€ / 5mg

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Description

BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.

Specifications

Chemical Name or Material	5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
Assay Percent Range	>98%
Molecular Formula	C₂₀H₁₅F₃N₄O₂

CAS	675103-36-3
Quantity	5 mg
Formula Weight	Observed MW: 400.35

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BAY 678

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