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BAY 678

Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor

Brand:  Tocris Bioscience 5706/25

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Product Code. 18741429

  • 455.00€ / 25mg

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Description

Description

BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
>98%
C20H15F3N4O2
675103-36-3
25 mg
Observed MW: 400.35
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