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DiscoverX cAMP Hunter™ CHO-K1 CCR7 Gi Cell Line
The cAMP Hunter™ CHO-K1 CCR7 Gi Cell Line measures CCR7 (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 95-0070C2
This item is not returnable.
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Description
The cAMP Hunter CCR7 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19) based activation of CCR7 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype CCR7 , a naturally Gi/Go coupled GPCR. Upon activation of CCR7 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
Intracellular cAMP level | |
Cell Lines | |
2 Vials | |
AY587876 |
CHO-K1 | |
Recombinant Human MIP-3β (CCL19) | |
CCR7 |
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