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DiscoverX cAMP Hunter™ CHO-K1 HTR1A Gi Cell Line
The cAMP Hunter™ CHO-K1 HTR1A Gi Cell Line measures HTR1A (GPCR) activity via decreased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 95-0132C2

Description
The cAMP Hunter HTR1A Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based activation of HTR1A GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wildtype HTR1A , a naturally Gi/Go coupled GPCR. Upon activation of HTR1A , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
Intracellular cAMP level | |
Cell Lines | |
2 Vials | |
NM_000524.2 |
CHO-K1 | |
Serotonin/5-HT | |
HTR1A |
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