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DiscoverX ChemiScreen™ BB1 Bombesin/Neuromedin B Receptor Stable Cell Line
The ChemiScreen™ BB1 Bombesin/Neuromedin B Receptor Stable Cell Line measures NMBR (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS123C
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Description
The ChemiScreen™ BB1 Bombesin/Neuromedin B Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bombesin, neuromedin B) based activation of NMBR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NMBR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NMBR , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials | |
| NM_002511.2 |
| Chem-1 | |
| Neuromedin B (porcine) | |
| NMBR |
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