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DiscoverX ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line
The ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line measures CYSLTR2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS088C
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Description
The ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. leukotriene) based activation of CYSLTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CYSLTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CYSLTR2 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials |
| Chem-1 | |
| Leukotriene C4 | |
| CYSLTR2 |
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Product Title
DiscoverX ChemiScreen™ CysLT2 Leukotriene Receptor Stable Cell Line
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