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DiscoverX ChemiScreen™ EP2 Prostanoid Receptor Stable Cell Line
The ChemiScreen™ EP2 Prostanoid Receptor Stable Cell Line measures PTGER2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS185C
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Description
The ChemiScreen™ EP2 Prostanoid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTGER2 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials | |
| AY275471 |
| Chem-9 | |
| Prostaglandin E2 | |
| PTGER2 |
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