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DiscoverX ChemiScreen™ μ Opioid Receptor Stable Cell Line
The ChemiScreen™ μ Opioid Receptor Stable Cell Line measures OPRM1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS101C
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Description
The ChemiScreen™ μ Opioid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. opioids) based activation of OPRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRM1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OPRM1 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials | |
| AY521028 |
| Chem-5 | |
| DAMGO(D-Ala2,N-Me-Phe4,Glu5-01)-Enkephalin Acetate Salt | |
| OPRM1 |
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