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DiscoverX ChemiScreen™ OX2 Orexin Receptor Stable Cell Line
The ChemiScreen™ OX2 Orexin Receptor Stable Cell Line measures HCRTR2 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS045C
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Description
The ChemiScreen™ OX2 Orexin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orexins) based activation of HCRTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HCRTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of HCRTR2 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials | |
| AF041245 |
| Chem-1 | |
| Orexin B | |
| HCRTR2 |
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