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DiscoverX ChemiScreen™ TSH Glycoprotein Hormone Receptor Stable Cell Line
The ChemiScreen™ TSH Glycoprotein Hormone Receptor Stable Cell Line measures TSHR (L) (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX HTS133C
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Description
The ChemiScreen™ TSH Glycoprotein Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TSH) based activation of TSHR (L) GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TSHR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TSHR , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Calcium Flux | |
| Cell Lines | |
| 2 Vials | |
| NM_000369.2 |
| Chem-10 | |
| TSH, Thyroid stimulating hormone, Human | |
| TSHR (L) |
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