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Eurofins DiscoverX EGFR (L858R) Protein, Active
Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R, for use in Enzyme Assays.
Brand: Eurofins DiscoverX 14-626
This item is not returnable.
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Description
Receptors that are tyrosine protein kinases include those receptors for epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin, and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in many cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. EGF receptor agonism may facilitate wound healing, enhance viral infections, topical inflammation and asthma as well as tumor cell proliferation and metastasis.
GenBank X00588
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥43% |
| 85.8 kDa | |
| Human | |
| N-terminal GST | |
| Truncated | |
| EGFR (L858R), active |