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DiscoverX KILR™ U2OS-EGFR Cell Line
The KILR™ U2OS-EGFR Cell Line allows for assay of effector-induced cell death by a variety of immune mechanisms. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 97-1010C003
This item is not returnable.
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Description
The KILR U2OS-EGFR cell line is a stable, engineered target cell line to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint inhibitors, checkpoint agonists, bispecifics, CAR-T, and more) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell line overexpresses a PL- tagged housekeeping gene as well as untagged EGFR. Once the cells have been lysed by effector cells, PL is released to the media, where EA contained in the detection kit produces an EFC signal proportional to the level of PL released. This allows for calculation of percent lysis of the KILR cell line. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| Cellular Cytotoxicity | |
| Cell Lines | |
| 2 Vials |
| U2OS | |
| Cetuximab | |
| EGFR |
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