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DiscoverX PathHunter™ CHO-K1 CCR4 β-Arrestin Cell Line
The PathHunter™ CHO-K1 CCR4 β-Arrestin Cell Line measures CCR4 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0193C2
This item is not returnable.
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Description
The PathHunter™ CCR4 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL22/MDC) based activation of CCR4 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged CCR4 and EA-tagged β-Arrestin 2. Activation of CCR4 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| AY322539 |
| CHO-K1 | |
| Recombinant Human MDC (CCL22) | |
| CCR4 |
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