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DiscoverX PathHunter™ CHO-K1 DRD2S (Short Isoform) β-Arrestin Cell Line
The PathHunter™ CHO-K1 DRD2S (Short Isoform) β-Arrestin Cell Line measures DRD2S (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0351C2
This item is not returnable.
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Description
The PathHunter™ DRD2S β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of DRD2S GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged DRD2S and EA-tagged β-Arrestin 2. Activation of DRD2S stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_016574.3 |
| CHO-K1 | |
| Dopamine HCl | |
| DRD2S |
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