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DiscoverX PathHunter™ CHO-K1 mCCR8 β-Arrestin Cell Line
The PathHunter™ CHO-K1 mCCR8 β-Arrestin Cell Line measures mCCR8 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Mouse protein.
Brand: DiscoverX 93-0556C2
This item is not returnable.
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Description
The PathHunter™ mCCR8 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL1) based activation of mCCR8 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged mCCR8 and EA-tagged β-Arrestin 2. Activation of mCCR8 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_007720.2 |
| CHO-K1 | |
| CCL1 (murine) | |
| mCCR8 |
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DiscoverX PathHunter™ CHO-K1 mCCR8 β-Arrestin Cell Line
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