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DiscoverX PathHunter™ CHO-K1 mCRTH2 β-Arrestin Cell Line
The PathHunter™ CHO-K1 mCRTH2 β-Arrestin Cell Line measures mCRTH2 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Mouse protein.
Brand: DiscoverX 93-0584C2
This item is not returnable.
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Description
The PathHunter™ mCRTH2 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of mCRTH2 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged mCRTH2 and EA-tagged β-Arrestin 2. Activation of mCRTH2 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_009962.2 |
| CHO-K1 | |
| Prostaglandin D2 | |
| mCRTH2 |
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