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DiscoverX PathHunter™ CHO-K1 MTNR1B β-Arrestin Cell Line
The PathHunter™ CHO-K1 MTNR1B β-Arrestin Cell Line measures MTNR1B (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0630C2
This item is not returnable.
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Description
The PathHunter™ MTNR1B β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. melatonin) based activation of MTNR1B GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged MTNR1B and EA-tagged β-Arrestin 2. Activation of MTNR1B stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
| β-Arrestin recruitment | |
| Cell Lines | |
| 2 Vials | |
| NM_005959.3 |
| CHO-K1 | |
| 2-Iodomelatonin | |
| MTNR1B |
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