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DiscoverX PathHunter™ CHO-K1 P2RY11 β-Arrestin Cell Line
The PathHunter™ CHO-K1 P2RY11 β-Arrestin Cell Line measures P2RY11 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.
Brand: DiscoverX 93-0281C2
This item is not returnable.
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Description
The PathHunter™ P2RY11 β-Arrestin cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP) based activation of P2RY11 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology (www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). The included cell line overexpresses PK-tagged P2RY11 and EA-tagged β-Arrestin 2. Activation of P2RY11 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.Specifications
β-Arrestin recruitment | |
Cell Lines | |
2 Vials | |
NM_002566.4 |
CHO-K1 | |
Adenosine 5′-triphosphate disodium salt hydrate | |
P2RY11 |
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